FibroScan™ — Tissue Fibrosis

Early, fiber‑specific detection of stromal remodeling in animal models and clinical specimens.

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FibroScan™ - Overviews

Sample types: Frozen cross-sections of rodent (kidney, liver, lung) & human biopsies

Read-out: Fluorescence imaging of fibronectin fibers and early-to-late fibrosis + fibrosis score

Co-imaging : Compatible with co-staining of specific proteins with antibodies (upto 2)

Available acquisition systems: Widefield slide scanner and confocal microscopy

Delivery: Raw data + High resolution specified montages + report

Turn-around: 2‑4 weeks from sample receipt

Inside the FibroScan™ workflow: From slide reception to analytic insight

For service requests or pricing, write to support@fibrocure.ch

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What we do

FibroScan™ applies fiber-sensitive probes to tissue cross-sections (5–20 µm) to reveal pre-collagenous fibronectin fibril scaffold associated with early fibrotic remodeling. Quantitative image analysis is then used to assess each region of interest and generate a fibrosis progression map.

Applications

FibroScan™ Research (preclinical)

Track fibrosis kinetics in UUO, CCl₄ liver injury, bleomycin lung models and others
Compare therapeutic candidates vs. standard controls
Identify early responders/non‑responders

FibroScan™ Translate (exploratory clinical)

Correlate ECM fiber state with pathology scores in transplant biopsies
Stratify tissue samples for ECM remodeling assessment
Build histology‑based tissue characterization indices

Deliverables

Following the service agreement terms we can deliver:

Fiber‑density quantifications (area & intensity)
High‑resolution montage images (PNG, TIF, SVG optional) and unprocessed raw images
Short interpretation report with key observations
Next‑step suggestions

Workflow

Here is a consistent workflow from a new project opening to the report and data delivery:

Project brief & quote (1 day)
Frozen section shipment & QC (3‑5 days)
Staining & imaging (1‑2 weeks)
Data analysis & draft report (5 days)
Interactive review call

Data snapshot

Validation

FibroScan™ – Research was validated on mouse models of kidney fibrosis, including UUO (unilateral ureteral obstruction) and POD (podocyte depletion) models.

FibroScan™ – Translate is currently being extended to human clinical samples, with successful detection achieved in a lung cancer biopsy. Additional specimen types, including other cancer tissues, are welcome and can be evaluated in collaboration with interested partners.

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