FibroScreen™ — ECM Response Monitoring ​

What we do

We expose your therapeutic candidates (small‑molecule, biologic or gene therapy) to cell cultures or cell spheroids and monitor fibronectin fibril formation with our low‑MW sensors. Because the probes bind only fibrotic fibronectin fibrils, even subtle ECM changes become visible within hours— before collagen deposition or cell transformation occurs.

Applications

• Monitor ECM fiber changes in response to therapeutic candidates
  
• Compare treatment effects on matrix organization 
  
• Evaluate biological agents targeting ECM pathways
  
• Support preclinical fibrosis studies
  

Deliverables

Following the service agreement terms we can deliver in time:

• Fiber‑density quantifications (area & intensity) 
• ECM response profiles for different treatment conditions
  
• High‑resolution montage images (PNG, TIF / MP4 optional) and the unprocessed raw images
• Short interpretation report with key observations
• Next‑step suggestions

Workflow

Here is a consistent workflow from project opening to report delivery:

1. Project brief & quote (1 day)
2. Sample shipment & QC (3‑5 days)
3. Assay run & imaging (1‑2 weeks)
4. Data analysis & draft report (5 days)
5. Interactive review call

Data samples

Validation

FibroScreen™ - ECM Response Monitoring was validated on several cell types including primary fibroblasts, human endothelial cells (HUVEC), several lung cancer cell lines including A549 lung, and patients-derived glioblastoma cells; extension remains possible to additional cell lines on request.

Request a FibroScreen™ quote